Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25μM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex format
MilliporeSigma™ Calbiochem™ Bisindolylmaleimide I, Hydrochloride
An enhanced water-soluble form of Bisindolylmaleimide I.
MilliporeSigma™ Calbiochem™ STAT3 Inhibitor XII, SPI
The STAT3 Inhibitor XII, SPI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Cathepsin K Inhibitor I
The Cathepsin K Inhibitor I controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ PP2A Activating Ligand, ITH12246
A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A)
MilliporeSigma™ Calbiochem™ Ornithine Decarboxylase Inhibitor, POB
The Ornithine Decarboxylase Inhibitor, POB controls the biological activity of Ornithine Decarboxylase.
MilliporeSigma™ Calbiochem™ PK11195
An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20
MilliporeSigma™ Calbiochem™ JHDM Inhibitor VIII, SD70
A cell-permeable, bioavailable, non-toxic 8-hydroxyquinolinyl based compound that binds to and colocalizes with androgen receptor (AR) at both ligand-dependent and independent transcriptional regulatory elements
MilliporeSigma™ Calbiochem™ Autophagy Inducer, STF-62247
A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.
MilliporeSigma™ Calbiochem™ HIF-1 Inhibitor
The HIF-1 Inhibitor, also referenced under CAS 934593-90-5, controls the biological activity of HIF-1.
MilliporeSigma™ Calbiochem™ Mitochondrial Citrate Transport Protein (CTP) Inhibitor
The Mitochondrial Citrate Transport Protein (CTP) Inhibitor, also referenced under CAS 412940-35-3, controls the biological activity of Mitochondrial Citrate Transport Protein (CTP).
MilliporeSigma™ Calbiochem™ bpV(bipy)
A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation).
MilliporeSigma™ Calbiochem™ IDH2 Inhibitor, R140Q Somatic Mutant-Specific, AGI-6780
A cell-permeable inhibitor of isocitrate dehydrogenase 2 R140Q mutant-containing dimers. Has minimal effect on wild type dimer-catalyzed alpha-KG production.
MilliporeSigma™ Calbiochem™ InSolution™ Akt Inhibitor X
The InSolution™ Akt Inhibitor X, also referenced under CAS 925681-41-0, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ PD 158780
A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC50 = 8 pM).